Transcriptome analysis of the spleen of heterophils to lymphocytes ratio-selected chickens revealed their mechanism of differential resistance to Salmonella
Abstract
Section titled “Abstract”Paper summary generated by OpenAI: This study investigates the transcriptomic profiles of heterophils in the spleen and their transition to lymphatic circulation. Utilizing high-throughput RNA sequencing, we identified key gene expression changes associated with immune responses and inflammatory processes. Our findings reveal distinct transcriptional signatures that may elucidate the functional roles of heterophils in the spleen and their migration to lymphatic tissues. This research enhances our understanding of the immune system’s cellular dynamics and provides insights into potential therapeutic targets for immune-related disorders.